CHCHD4 links AIF to the biogenesis of respiratory chain complex I
نویسندگان
چکیده
منابع مشابه
Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery. Depletion or hypomorphic mutation of AIF caused a downregulat...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2015
ISSN: 2372-3556
DOI: 10.1080/23723556.2015.1074332